https://www.schwartzlab.mit.edu/contact-us daily 0.75 2020-11-11 https://www.schwartzlab.mit.edu/research daily 0.75 2021-01-09 https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1604929398531-FM09KMIP450URR47PPA3/image-asset.jpeg Research - Transport across the nuclear envelope Unlike other membranes, the nuclear envelope has only one known transporter for molecular exchange – the Nuclear Pore Complex (NPC). About 2000 NPCs perforate the nuclear envelope in a human cell and the simple question we ask is: How is it structured and how does it fulfill its myriad functions? Over the past decade we have published many crystal structures of NPC fragments and subcomplexes, which are now being used to assemble the core scaffold of the ~50 MDa complex in combination with cryo-EM/ET images. We have established that the NPC is structurally and evolutionarily linked to vesicle coats, which helps in deciphering its mode of action. We are now entering a new phase, in which we will ask specific functional questions, based on the structural principles that we have helped to establish. These questions include transport of specific cargo classes, cell-specific variations of the NPC composition, viral transport, and emerging transport-unrelated topics. https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1604929167728-LFDLFM6TX992W53UIOK9/nihms378425f6.jpg Research - Mechanical connection between nucleus and cytoskeleton Mechanical linkers traversing the nuclear envelope are necessary to keep the nucleus in a specific location within the cell. A wide variety of genetic diseases are caused by mutations within proteins involved in establishing these bridges. We ask how these bridges are set up and how they are regulated. Using innovative biochemical methods we have established the structural basis for the LINC complex (Sosa et al., Cell 2012; Cruz et al., J Mol Biol 2020), the centerpiece of the mechanical tether. Current projects include the characterization, functionally and structurally, of all elements that contribute to connecting the cytoskeleton with the nucleoskeleton. https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1604929557097-Y5BZB2CK8YO7G75MTINT/6oif.pdb1-500.jpg Research - Torsin - Primary Dystonia We are investigating TorsinA, an ER-resident AAA+ ATPase. A single glutamate deletion at position 303 of the protein is the main cause for the genetic, neuromuscular disease Primary Dystonia. The etiology of the disease is still largely enigmatic. Through structural analysis by crystallography and cryo-electron microscopy, we have discovered key principles of this unusual enzyme and are now engaged in further deciphering its function, and we are trying to find small molecules as potential drug candidates. https://www.schwartzlab.mit.edu/publications daily 0.75 2024-01-31 https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605114079728-X2W8Z921Z7W7IR5EHYUR/image-asset.png Publications 1XKS https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605060375581-ZDJ5GYH80NBOCVWFXWST/5TJW.png Publications 5TJW https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605111256757-36UBIY2CJNRYDN69QSO8/3I4R.png Publications 3I4R https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605113051268-9D0HO8JYDUXFNVJ9NQ4Z/3GJ4.png Publications 3GJ3 | 3GJ4 | 3GJ5 | 3GJ6 | 3GJ7 3GJ8 https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605062758140-UD8IQRZKWSNQ2Y32YUYD/4YCZ.png Publications 4YCZ https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605063851763-YC0XP8TST70VJGQQN410/4KF7.png Publications 4KF7 https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605110336999-H6B2RFIDMMQA52ABS4HY/image-asset.png Publications 3HD1 https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605113462503-6X28QYGLVU59GUTNBHRA/3CQG.png Publications 3CQG https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605113967383-K7WKFZZAD1A5SXL2JXT5/image-asset.png Publications 2GED https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605060217922-FE86VU27668PYYT098FQ/5UKB.png Publications 5UKB https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605110667891-6RR2NCQQCHIZL8YQSCA2/image-asset.png Publications 3JRP https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605110157938-X2M8QHGD229MY2N6CPKI/3MZL.png Publications 3MZL https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605063873560-H2X77ZJKHLPQXGYKQFBG/4KF8.png Publications 4KF8 https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605111485820-1DR442MSC8D4TLWGZ56X/3HXR.png Publications 3HXR https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605060129104-27NXOUTSPG5FG0HGO98T/5UK4.png Publications 5UK4 https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605111287450-EOJBBITWTU4NSYJD5AUC/3I5P.png Publications 3I5P https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605110546809-0K2YXFZ8K53AP26N52B5/image-asset.png Publications 3JRO https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605113236390-48YI2D8YOJDQ872G4KTT/image-asset.png Publications 3EWE https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605059643697-6M5Y1DL2RHQT65802Q42/6OIF.png Publications 60IF https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605113647429-WXT2320CN7K7C2S0P81M/2QX5.png Publications 2QX5 https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605061134493-HI2HBGRANHVND64V9TWX/5J1S.png Publications 5J1S | 5J1T https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605063619778-4SGNB4SFU20BY1GYR2FR/4TVS.png Publications 4TVS https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605109547109-0UYT46YAHAIJKYYUOQT2/4FHN.png Publications 4FHL | 4FHM | 4FHN | 4FCC https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605061739723-KN2456P8T2GLT4NZXAVX/5DJ4.png Publications 5DJ4 https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605110187166-P7OWXR4JBBM2YH8ZWIZ0/3MZK.png Publications 3MZK https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605109846675-4KGQAIC284PJF3JIBQRL/image-asset.png Publications 4DXR | 4DXS | 4DXT https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605062531794-2XYINLR02ZYK2VH49N2V/4YD8.png Publications 4YD8 https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605111354902-BWLAYJ4MWI7W7GLB1A4M/3I5Q.png Publications 3I5Q https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605062156181-28ZLGXF6M3CMJGLQNC6O/4YGA.png Publications 4YGA https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605061766591-PPYLS0QV8OADSB3GJBFQ/5JJ6.png Publications 5JJ6 | 5JJ7 https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605064042757-A3774QBYOF8F3HTPZ1Y7/4I0O.png Publications 4I0O https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605061342061-XR5O04MYNGRQGZ3UNGCE/5I2C.png Publications 5I2C https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605111998706-8SWHO38CX5YI0TFVDMBB/3GJ0.png Publications 3GJ0 https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605060557452-VGZ9QZVAPHYXX40L4TXE/5T0N.png Publications 5T0N https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605113437247-RUPGCQ4XJ2KVY6G9T6LV/3CQC.png Publications 3CQC https://www.schwartzlab.mit.edu/members daily 0.75 2025-10-30 https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605114256022-XULXGWE0OQDUE31CZ3KU/ThomasPic.png Members https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1f5457ab-a687-46e0-ad98-e957917c3f1a/tempImagexfwf5i.jpg Members https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/e361f88f-d180-4881-97ed-9731af307491/Prachi.jpg Members https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/c5593a2a-5389-4d4f-8390-31a2aba946ea/IMG_2433.jpg https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/55119441-9f2c-49fa-a48b-98179e164994/Matt-LabWebsite.jpg https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/cc134357-8750-4b2f-9f84-0f7b9a0afea4/Mario-LabWebsite.jpg https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/f29339d4-492f-4454-96c8-6c32f310fe85/Jess+photo.jpg https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/5782ccd2-4542-4cdf-82f2-4decdbea6f1c/Rita-LabWebsite.jpg https://www.schwartzlab.mit.edu/lab-fun daily 0.75 2024-02-09 https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/912348a3-ac81-46d1-b744-eda1a4f6399e/IMG_5562.GIF Lab Fun - Make it stand out The Resolution Revolution hits the MIT Bio Halloween party! https://images.squarespace-cdn.com/content/v1/5fa7eb38bf7ccf12b43733b2/1605055853203-6K4O8AYF0XHSOXP4M5W7/image2.JPG Lab Fun Cheesing in front of our new Talos Arctica! 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with the Vos lab at the Cheesecake Factory! https://www.schwartzlab.mit.edu/home daily 1.0 2024-02-09 https://www.schwartzlab.mit.edu/jobs daily 0.75 2021-02-06 https://www.schwartzlab.mit.edu/book-a-class daily 0.75 2025-05-12